Abstract | BACKGROUND: MATERIALS AND METHODS: RESULTS: In the combination group, NF-κB activation was inhibited and apoptosis was enhanced compared with gemcitabine alone in vitro and vivo. Tumor growth in the combination group was significantly slower than that in the gemcitabine group (P < 0.001). At the end of the study, the tumor weight and volume in the combination group were significantly lower than those in the gemcitabine group (P = 0.039 and 0.028, respectively). CONCLUSIONS:
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Authors | Ryota Iwase, Koichiro Haruki, Yuki Fujiwara, Kenei Furukawa, Hiroaki Shiba, Tadashi Uwagawa, Takeyuki Misawa, Toya Ohashi, Katsuhiko Yanaga |
Journal | The Journal of surgical research
(J Surg Res)
Vol. 184
Issue 1
Pg. 605-12
(Sep 2013)
ISSN: 1095-8673 [Electronic] United States |
PMID | 23830367
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 Elsevier Inc. All rights reserved. |
Chemical References |
- Antimetabolites, Antineoplastic
- Benzamidines
- Guanidines
- NF-kappa B
- Serine Proteinase Inhibitors
- Deoxycytidine
- nafamostat
- Gemcitabine
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Topics |
- Animals
- Antimetabolites, Antineoplastic
(pharmacology)
- Apoptosis
(drug effects)
- Benzamidines
- Carcinoma
(drug therapy, pathology)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Deoxycytidine
(analogs & derivatives, pharmacology)
- Drug Resistance, Neoplasm
- Drug Therapy, Combination
- Gallbladder Neoplasms
(drug therapy, pathology)
- Guanidines
(pharmacology)
- Humans
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- NF-kappa B
(metabolism)
- Serine Proteinase Inhibitors
(pharmacology)
- Xenograft Model Antitumor Assays
- Gemcitabine
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