Scabies is a common parasitic infestation that is an important public-health problem in many resource-poor regions. It is commonly treated with the
insecticides but the treatment of choice is still controversial. This study aimed at comparing the efficacy of
permethrin 2.5% cream vs. Tenutex
emulsion for the treatment of
scabies. In total, 440 patients with
scabies were enrolled, and randomized into two groups The first group received
permethrin 2.5% cream twice with one week interval and the second group received Tenutex
emulsion and were told to apply this once whole-body application. Treatment was evaluated at intervals of 2 and 4 weeks, and if there was treatment failure at the 2-week follow-up, treatment was repeated.Two application of
permethrin 2.5% cream provided a cure rate of 63.6% at the 2-week follow-up, which increased to 86.3% at the 4-week follow-up after repeating the treatment. Treatment with single applications of Tenutex
emulsion was effective in 45.4% of patients at the 2-week follow-up, which increased to 59.1% at the 4-week follow-up after this treatment was repeated.Two application of
permethrin 2.5% cream was as effective as single applications of Tenutex
emulsion at the 2-week follow-up. After repeating the treatment,
permethrin 2.5% cream was superior to Tenutex
emulsion at the 4-week follow up.