Abstract | AIM: Radiopeptide therapy with beta emitter labeled (177)Lu/(90)Y- DOTA(0)-Phe(1)-Tyr(3)-octreotide ( DOTATOC) and more recently also alpha emitting (213)Bi-DOTATOC are promising new treatments for neuroendocrine tumors. No early predictors for treatment response have been recognized and tumor-shrinkage after radiation therapy appears slowly. In some solid tumors a decline in tumor perfusion was found predictive of final treatment response but the gold standard multiphase computed tomography (CT) has a high radiation burden. Therefore we evaluated the ability of contrast-enhanced ultrasound (CEUS) to evaluate tumor perfusion as a response criteria. MATERIALS AND METHODS: 14 patients with hepatic neuroendocrine tumor (NET) metastases were enrolled in the retrospective study. Eleven patients were treated with beta-emitting (177)Lu/(90)Y- DOTATOC, either intravenous (i.v.) (n = 5) or intra-arterial (i.a.) (n = 6) and three patients received alpha-emitting (213)Bi-DOTATOC (i.a.). CEUS and contrast-enhanced CT (CE-CT) were performed before and 3 months after treatment. RESULTS: CE-CT and CEUS presented comparable results in the baseline study and in the assessment of perfusion changes due to the different treatment regimes. A therapy related decrease in tumor perfusion is an early predictor of longterm morphologic response. CONCLUSION: CEUS is available and radiation free technique which showed comparable results for perfusion and diameter of liver metastases compared to CE-CT. Intensity reduction in an arterial phase CEUS can be seen as a positive sign indicating long term tumor response to treatment. Therefore CEUS may be considered as an imaging modality for monitoring early treatment after focal alpha and beta targeted therapy.
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Authors | F L Giesel, S Wulfert, C M Zechmann, U Haberkorn, C Kratochwil, P Flechsig, T Kuder, L H Schwartz, F Bruchertseifer |
Journal | Experimental oncology
(Exp Oncol)
Vol. 35
Issue 2
Pg. 122-6
(Jun 2013)
ISSN: 1812-9269 [Print] Ukraine |
PMID | 23828389
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- 177Lu-octreotide, DOTA(0)-Tyr(3)-
- Contrast Media
- Radioisotopes
- 90Y-octreotide, DOTA-Tyr(3)-
- Octreotide
- Bismuth
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Topics |
- Bismuth
- Contrast Media
- Infusions, Intra-Arterial
- Liver Neoplasms
(diagnostic imaging, pathology, radiotherapy)
- Neuroendocrine Tumors
(diagnostic imaging, pathology, radiotherapy)
- Octreotide
(analogs & derivatives, therapeutic use)
- Pancreatic Neoplasms
(pathology, surgery)
- Perfusion Imaging
- Positron-Emission Tomography
(methods)
- Radioisotopes
(therapeutic use)
- Retrospective Studies
- Tomography, X-Ray Computed
(methods)
- Treatment Outcome
- Ultrasonography
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