Resistant hypertension.

Abstract

UNLABELLED:

A 53 year old woman with hypercholesterolemia treated with statins, with no history of cardiovascular disease, was referred to the Hypertension and Vascular Risk Unit for management of hypertension resistant to 4 antihypertensive agents at full doses. The patient had obesity, with a body mass index of 36.3kg/m(2) and office blood pressure 162/102mm Hg. Physical examination showed no data of interest.

ANALYSIS:

glucose 120mg/dl, glycated Hb: 6.4%, albuminuria 68mg/g, kidney function and study of the renin angiotensin system and other biochemical parameters were normal. Echocardiography: left ventricular mass, 131g/m(2) (normal, <110g/m(2)). True resistant hypertension was confirmed by ambulatory monitoring of blood pressure during 24h (153/89mm Hg). Spironolactone treatment (25mg/day) was added and was well tolerated, with no change in renal function and kaliemia within normal (4.1mmol/l) following the treatment. After 8 weeks, blood pressure was well controlled: office blood pressure 132/86mm Hg and 24h-ambulatory blood pressure: 128/79mm Hg.

• Authors: P Armario, A Oliveras, A de la Sierra
• Journal: Revista clinica espanola (Rev Clin Esp (Barc)) Vol. 213 Issue 8 Pg. 388-93 (Nov 2013) ISSN: 2254-8874 [Electronic] Spain
• PMID: 23827205 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2013 Elsevier España, S.L. All rights reserved.

Chemical References

• Antihypertensive Agents
• Diuretics
• Spironolactone

Topics

• Antihypertensive Agents (therapeutic use)
• Diuretics (therapeutic use)
• Drug Resistance
• Female
• Humans
• Hypertension (drug therapy)
• Middle Aged
• Spironolactone (therapeutic use)