Abstract | OBJECTIVE: METHODS: Between 2008 January and 2009 December, 367 patients received chemotherapy or HSCT from 15 medical centers in China were collected. The strategies of antifungal therapy and the first-choice antifungal agents were analyzed. RESULTS: Of them, 282(76.8%) patients received empirical antifungal therapy, 85(23.2%) preemptive therapy. The number of first choice antifungal agents were 55(15.0%) of fluconazole, 174(47.4%) of itraconazole, 39(10.6%) of voriconazole, 57(15.5%) of traditional/ lipid formulation amphotericin B, 26(7.1%) of caspofungin, 7(1.9%) of micafungin, and 9(2.5%) of combination antifungal therapy respectively. Moreover, voriconazole and combination antifungal agents were more often selected for preemptive antifungal therapy, while the probabilities of itraconazole were the highest in both empirical and preemptive strategies. More patients undergoing HSCT were first given itraconazole or caspofungin for antifungal therapy, while amphotericin B, fluconazole and voriconazole were more administered in patients received chemotherapy. Caspofungin and combined antifungal agents were more often used for patients with secondary antifungal prophylaxis, while itraconazole was usually used for patients with no prophylaxis or primary antifungal prophylaxis. CONCLUSION:
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Authors | Yu Ji, Lan-ping Xu, Xiao-jun Huang |
Journal | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
(Zhonghua Xue Ye Xue Za Zhi)
Vol. 34
Issue 6
Pg. 473-7
(Jun 2013)
ISSN: 0253-2727 [Print] China |
PMID | 23827099
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antifungal Agents
- Antineoplastic Agents
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Topics |
- Adult
- Antibiotic Prophylaxis
- Antifungal Agents
(therapeutic use)
- Antineoplastic Agents
(therapeutic use)
- China
(epidemiology)
- Female
- Hematologic Neoplasms
(drug therapy, microbiology)
- Humans
- Male
- Middle Aged
- Mycoses
(prevention & control)
- Young Adult
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