Abstract | BACKGROUND: METHODS: In 91 patients Ang-2 and NT-proBNP were measured and related to New York Heart Association class, systemic ventricular function and parameters of cardiopulmonary exercise testing. Ang-1, VEGF, and sTie2 were also measured. RESULTS: Ang-2 correlates with NYHA class and ventricular dysfunction comparable to NT-proBNP. Further, Ang-2 showed a good correlation with parameters of cardiopulmonary exercise testing. Both, Ang-2 and NT-proBNP identified patients with severely limited cardiopulmonary exercise capacity. Additionally, Ang-2 is elevated in patients with a single ventricle physiology in contrast to NT-proBNP. VEGF, Ang-1, and sTie2 were not correlated with any clinical parameter. CONCLUSION: The performance of Ang-2 as a biomarker for heart failure in ACHD is comparable to NT-proBNP. Its significant elevation in patients with single ventricle physiology indicates potential in this patient group and warrants further studies.
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Authors | Alexander Lukasz, Gernot Beutel, Philipp Kümpers, Agnieszka Denecke, Mechthild Westhoff-Bleck, Bernhard Schieffer, Johann Bauersachs, Jan T Kielstein, Oktay Tutarel |
Journal | PloS one
(PLoS One)
Vol. 8
Issue 6
Pg. e66861
( 2013)
ISSN: 1932-6203 [Electronic] United States |
PMID | 23826161
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiopoietin-1
- Angiopoietin-2
- Biomarkers
- Peptide Fragments
- Vascular Endothelial Growth Factor A
- pro-brain natriuretic peptide (1-76)
- Natriuretic Peptide, Brain
- Receptor, TIE-2
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Topics |
- Adult
- Angiopoietin-1
(blood)
- Angiopoietin-2
(blood)
- Biomarkers
(blood)
- Exercise
- Female
- Heart Defects, Congenital
(blood, physiopathology)
- Heart Failure
(blood, physiopathology)
- Heart Function Tests
- Heart Ventricles
(physiopathology)
- Humans
- Male
- Natriuretic Peptide, Brain
(blood)
- Peptide Fragments
(blood)
- Receptor, TIE-2
(metabolism)
- Vascular Endothelial Growth Factor A
(blood)
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