Abstract | AIMS: METHODS: Included were infants of the 2009 prospective ROP inventory in The Netherlands with gestational age (GA) <32 weeks and/or birth weight (BW) <1500 g. Five models were studied, based on GA and BW in combination with no, one or a set of five risk factors for ROP. Risk factors were determined by logistic regression. In MEDLINE and EMBASE, additional risk factors were searched. A precondition was that no infants with severe ROP would be missed. Receiver operating characteristic curves or classical measures were used to determine diagnostic accuracy. RESULTS: The model including all infants with severe ROP comprised screening of infants with GA <30 weeks and/or BW <1250 g and a selection of infants with GA 30-32 weeks and/or BW 1250-1500 g, with at least one of the following risk factors: artificial ventilation (AV), sepsis, necrotising enterocolitis (NEC), postnatal glucocorticoids or cardiotonica. This model would not detect 4.8% (95% CI 2.5% to 8.0%) of infants with mild ROP and would reduce infants eligible for screening by 29%. CONCLUSIONS: In The Netherlands, screening may be safely reduced using a new guideline based on GA, BW, AV, sepsis, NEC, postnatal glucocorticoids and cardiotonica.
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Authors | A J van Sorge, N E Schalij-Delfos, F T Kerkhoff, L J van Rijn, J L A M van Hillegersberg, I L A van Liempt, P G M Peer, H J Simonsz, J U M Termote |
Journal | The British journal of ophthalmology
(Br J Ophthalmol)
Vol. 97
Issue 9
Pg. 1143-7
(Sep 2013)
ISSN: 1468-2079 [Electronic] England |
PMID | 23823079
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Female
- Humans
- Incidence
- Infant, Newborn
- Infant, Premature
- Logistic Models
- Male
- Mass Screening
(organization & administration)
- Neonatal Screening
(methods)
- Netherlands
(epidemiology)
- Practice Guidelines as Topic
- Retinopathy of Prematurity
(diagnosis, epidemiology)
- Risk Factors
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