Profiling of the calcitonin-calcitonin receptor axis in primary prostate cancer: clinical implications and molecular correlates.

Abstract

Expression of the neuroendocrine peptide calcitonin (CT) and its receptor (CTR) is frequently elevated in prostate cancers (PCs), and activation of the CT-CTR axis in non-invasive PC cells induces an invasive phenotype. We aimed to link CT/CTR expression in prostate specimens to clinicopathological parameters of PC. We analyzed CT and CTR expression in cohorts of benign prostates and primary PCs with/without metastatic disease by immunohistochemistry. Furthermore, we correlated CT/CTR expression with several clinicopathological parameters. CT/CTR immunostaining in benign prostate acini was predominantly localized to basal epithelium. However, this spatial specificity was lost in malignant prostates. PC sections displayed a remarkable increase in cell populations expressing CT/CTR and their staining intensity. Tumors with higher CT/CTR expression consistently displayed metastatic disease and poor clinical outcome. High CT/CTR expression in primary prostate tumors may serve as a prognostic indicator of disease aggressiveness and poor clinical outcome.

• Authors: Arvind Thakkar, Irene V Bijnsdorp, Albert A Geldof, Girish V Shah
• Journal: Oncology reports (Oncol Rep) Vol. 30 Issue 3 Pg. 1265-74 (Sep 2013) ISSN: 1791-2431 [Electronic] Greece
• PMID: 23820954 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Biomarkers, Tumor
• Receptors, Calcitonin
• Calcitonin

Topics

• Aged
• Aged, 80 and over
• Biomarkers, Tumor (metabolism)
• Calcitonin (metabolism)
• Cohort Studies
• Fluorescent Antibody Technique
• Follow-Up Studies
• Humans
• Immunoenzyme Techniques
• Male
• Middle Aged
• Neoplasm Grading
• Neoplasm Metastasis
• Neoplasm Staging
• Prognosis
• Prostate (metabolism, pathology)
• Prostatic Hyperplasia (metabolism, mortality, pathology)
• Prostatic Neoplasms (metabolism, mortality, pathology)
• ROC Curve
• Receptors, Calcitonin (metabolism)
• Survival Rate
• Tissue Array Analysis