Abstract | BACKGROUND: Autologous peripheral blood stem cell transplantation (PBSCT) is commonly used in the treatment of lymphoma patients. G-CSF is widely used to boost white blood cell recovery. However, there are no clear data indicating which strategy of using G-CSF provides the most benefit. The aim of our study was to compare 3 strategies of G-CSF administration: from day +1, from day +5, and no administration. MATERIAL AND METHODS: Data from 211 patients treated at 3 centers were gathered retrospectively. The patients in the 3 analyzed groups were not different in regard to type of disease, age, sex, and number of CD34+ cells received. RESULTS: The 3 strategies of G-CSF dosage had very similar results. G-CSF boosted the recovery of white blood cells and shortened the time of neutropenia. However, there were no differences in confirmed infections and the duration of hospitalization after transplantation. CONCLUSIONS: Our results question the use of G-CSF in a post-PBSCT setting, as it does not provide significant benefits in reducing the number of infections or shortening the duration of hospitalization.
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Authors | Iwona Wyleżoł, Emilian Snarski, Mirosław Markiewicz, Sławomira Kyrcz-Krzemień, Wiesław-Wiktor Jędrzejczak, Jan Walewski |
Journal | Annals of transplantation
(Ann Transplant)
Vol. 18
Pg. 336-41
(Jul 02 2013)
ISSN: 2329-0358 [Electronic] United States |
PMID | 23817440
(Publication Type: Comparative Study, Journal Article, Multicenter Study)
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Chemical References |
- Hematinics
- Granulocyte Colony-Stimulating Factor
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Topics |
- Adult
- Aged
- Autografts
- Combined Modality Therapy
- Drug Administration Schedule
- Female
- Granulocyte Colony-Stimulating Factor
(administration & dosage)
- Hematinics
(administration & dosage)
- Humans
- Infection Control
- Length of Stay
- Leukocyte Count
- Lymphoma
(blood, drug therapy, therapy)
- Male
- Middle Aged
- Peripheral Blood Stem Cell Transplantation
(methods)
- Poland
- Retrospective Studies
- Young Adult
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