No association between mitochondrial tRNA(Val) T1658C mutation and chronic progressive external ophthalmoplegia (CPEO).

Abstract

Mutations in mitochondrial tRNA genes are one of the most important causes of mitochondrial diseases. Recently, a novel mt-tRNA(Val) T1658C mutation has been reported to be associated with chronic progressive external ophthalmoplegia (CPEO). To test this association, we performed a phylogenetic analysis of T1658C mutation, moreover, we used the bioinformatic tool to predict the thermodynamic change of tRNA(Val) with and without this mutation. Surprisingly, T1658C mutation was not evolutionary conserved and had little effect on tRNA(Val) folding. These data indicated that T1658C mutation should still be categorized as a polymorphism.

• Authors: Lijun Zhou, Hongwei Wang, Jing Wei, Yi Wang, Yanyu Wang
• Journal: Mitochondrial DNA (Mitochondrial DNA) Vol. 25 Issue 5 Pg. 385-6 (Oct 2014) ISSN: 1940-1744 [Electronic] England
• PMID: 23815321 (Publication Type: Journal Article)

Chemical References

• RNA, Mitochondrial
• RNA, Transfer, Val
• RNA

Topics

• Computational Biology (methods)
• Genetic Association Studies
• Humans
• Nucleic Acid Conformation
• Ophthalmoplegia, Chronic Progressive External (genetics)
• Phylogeny
• Point Mutation
• RNA (genetics)
• RNA, Mitochondrial
• RNA, Transfer, Val (genetics)
• Thermodynamics