Unusual clinical course of preeclampsia heralded by generalized edema.

Abstract

Preeclampsia monitored by the amount of proteinuria usually does not show amelioration during pregnancy. A 37-year-old nulliparous woman was admitted to our hospital at gestational week (GW) 24(-1/7) due to rapid weight gain (6.2 kg/4 weeks) and oligohydramnios. Hypertension (151/91 mmHg) appeared at GW 25(-0/7) and proteinuria not detected at GW 24(-0/7) became significant (0.55 g/day) at GW 25(-2/7) . During the 2 successive weeks after administration of betamethasone at 12 mg twice and transabdominal amnioinfusion with 250 mL of Ringer's acetate solution at GW 25(-3/7) , generalized edema, proteinuria and thrombocytopenia markedly improved: bodyweight, 78.0 to 69.0 kg; proteinuria, from 7.1 to 1.3 g/day; and platelet count, from 111 to 230 × 10(9) /L. However, intrauterine infection accompanied by non-reassuring fetal status necessitated emergency cesarean section at GW 28(-3/7) . Extraordinary bodyweight gain can herald the occurrence of preeclampsia and this weight gain together with signs of preeclampsia can ameliorate even during pregnancy, although its mechanism is unclear.

• Authors: Takashi Kojima, Takahiro Yamada, Takashi Yamada, Mamoru Morikawa, Kazutoshi Cho, Hisanori Minakami
• Journal: The journal of obstetrics and gynaecology research (J Obstet Gynaecol Res) Vol. 39 Issue 11 Pg. 1538-40 (Nov 2013) ISSN: 1447-0756 [Electronic] Australia
• PMID: 23815168 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2013 The Authors. Journal of Obstetrics and Gynaecology Research © 2013 Japan Society of Obstetrics and Gynecology.

Topics

• Adult
• Edema (etiology)
• Female
• Humans
• Pre-Eclampsia
• Pregnancy
• Remission, Spontaneous