[General anesthetic management of a patient with spinal muscular atrophy type III].

We report a 61-year-old woman (weight 49 kg, height 156 cm) with Kugelberg-Welander disease who was scheduled for bilateral mastectomy under general anesthesia. We administered rocuronium 10 mg (0.20 mg x kg(-1)) for tracheal intubation. After 80 min, train-of-four ratio (TOFR) was 46%. During the operation, we did not administer rocuronium. After surgery, TOFR was 62%. Therefore, we administered sugammadex 100 mg (2 mg x kg(-1)). After 4 min, TOFR became above 90%, and the patient was extubated. There was no respiratory distress, muscle weakness, or neurologic untoward event after the use of sugammadex in the postoperative period. Sugammadex was effective in reversing rocuronium induced neuromuscular block in a patient with Kugelberg-Welander disease.
AuthorsMasayuki Inamori, Yasuhiko Imashuku, Shota Sonobe, Chikahiko Sukenaga, Koichi Yabuta, Toshiya Hashimura, Masahiro Kura, Hideki Otada
JournalMasui. The Japanese journal of anesthesiology (Masui) Vol. 62 Issue 6 Pg. 702-4 (Jun 2013) ISSN: 0021-4892 [Print] Japan
PMID23814997 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Androstanols
  • Neuromuscular Nondepolarizing Agents
  • gamma-Cyclodextrins
  • Sugammadex
  • rocuronium
  • Androstanols (administration & dosage)
  • Anesthesia, General (methods)
  • Female
  • Humans
  • Intubation, Intratracheal (methods)
  • Mastectomy
  • Middle Aged
  • Neuromuscular Monitoring
  • Neuromuscular Nondepolarizing Agents (administration & dosage)
  • Spinal Muscular Atrophies of Childhood (complications)
  • gamma-Cyclodextrins (administration & dosage)

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