Abstract | PURPOSE: METHODS: RESULTS: All EP receptors were expressed in NPDFs. PGE2 significantly increased VEGF production concentration- and time dependently, and VEGF production was regulated by an EP4 receptor. Activation of intracellular cAMP regulated VEGF production. VEGF production was decreased by PKA and PI3K inhibitors via intracellular cAMP. CONCLUSIONS:
PGE2 stimulates VEGF production via the EP4 receptor in NPDFs. These results indicate that PGE2-induced VEGF production is mediated, at least partially, through cAMP-dependent signaling pathways. Therapies targeting the EP4 receptor may be effective in inhibiting the development of nasal polyps.
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Authors | Dong Yeol Han, Jung-Sun Cho, You-Mi Moon, Hye-Rim Lee, Heung-Man Lee, Byung Don Lee, Byoung Joon Baek |
Journal | Allergy, asthma & immunology research
(Allergy Asthma Immunol Res)
Vol. 5
Issue 4
Pg. 224-31
(Jul 2013)
ISSN: 2092-7355 [Print] Korea (South) |
PMID | 23814676
(Publication Type: Journal Article)
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