New long circulating magnetoliposomes as contrast agents for detection of ischemia-reperfusion injuries by MRI.

Abstract

New long circulating magnetoliposomes coated with polyethylene glycol (PEG), and loaded with PEG-coated 10nm superparamagnetic iron oxide nanoparticles (SPION), were developed. The magnetoliposomes relaxivities r1, r2 measured in a magnetic field of 7 T showed a minor effect on T1, but a major effect on T2. These nanosystems were used as a negative contrast agent for MRI in a nonclinical study to visualize, in a rat model of liver ischemia, ischemia-reperfusion injuries. Magnetic resonance micro-images (MRM) at 7 T were obtained for rat liver with and without magnetoliposomes administration and analyzed in comparison with liver biomarkers and histological results. These new long circulating magnetoliposomes enhanced the detection of lesions indicating their potential use as efficient MRI negative contrast agent for the detection of liver ischemia-reperfusion injuries.

FROM THE CLINICAL EDITOR:

This paper describes the generation of PEGylated magnetoliposomes and demonstrates their feasibility as negative contrast agents in a liver ischemia-reperfusion rat model.

• Authors: M Bárbara A F Martins, M Luísa Corvo, Paulo Marcelino, H Susana Marinho, Gabriel Feio, Alexandra Carvalho
• Journal: Nanomedicine : nanotechnology, biology, and medicine (Nanomedicine) Vol. 10 Issue 1 Pg. 207-14 (Jan 2014) ISSN: 1549-9642 [Electronic] United States
• PMID: 23811291 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2013.

Chemical References

• Contrast Media
• Ferric Compounds
• Liposomes
• Magnetite Nanoparticles
• ferric oxide
• Polyethylene Glycols

Topics

• Animals
• Contrast Media
• Ferric Compounds (chemistry)
• Humans
• Liposomes (administration & dosage, chemistry)
• Liver (diagnostic imaging, pathology)
• Magnetic Resonance Angiography
• Magnetite Nanoparticles (chemistry)
• Polyethylene Glycols (chemistry)
• Radiography
• Rats
• Reperfusion Injury (diagnosis, diagnostic imaging)