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Protective effect of augmenter of liver regeneration on vincristine-induced cell death in Jurkat T leukemia cells.

Abstract
Augmenter of liver regeneration (ALR) is a crucial factor in the process of proliferation of hepatocytes. Recently, it has been demonstrated that ALR plays an important role of anti-apoptosis in several cell lines, but the biological effects of ALR in acute T lymphoblastic leukemia have remained unclear. In this study, we investigated the effect of ALR on Jurkat T leukemia cell growth and survival. We found that ALR was up-regulated in Jurkat cells and could reduce the sensitivity of Jurkat cells to vincristine, but had a minimal effect on proliferation of Jurkat cells. Results from analysis of flow cytometry showed ALR attenuated apoptotic cells and inhibited G2/M-arrest in vincristine-treated Jurkat cells. Following incubation with ALR, an increase in pro-caspase8, pro-caspase3, pro-PARP and Bcl-2 levels was observed in vincristine-treated Jurkat cells. In summary, the results of this study demonstrate that ALR protects Jurkat T leukemia cells from vincristine-induced cell death via regulation of apoptotic signaling pathways and cell cycle.
AuthorsYan Shen, Qi Liu, Hang Sun, Xiaofang Li, Na Wang, Hui Guo
JournalInternational immunopharmacology (Int Immunopharmacol) Vol. 17 Issue 2 Pg. 162-7 (Oct 2013) ISSN: 1878-1705 [Electronic] Netherlands
PMID23810409 (Publication Type: Journal Article)
CopyrightCopyright © 2013 Elsevier B.V. All rights reserved.
Chemical References
  • Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • augmenter of liver regeneration factor
  • Vincristine
  • Parp1 protein, mouse
  • Poly (ADP-Ribose) Polymerase-1
  • Poly(ADP-ribose) Polymerases
  • Caspase 3
  • Caspase 8
Topics
  • Caspase 3 (metabolism)
  • Caspase 8 (metabolism)
  • Cell Death (drug effects, immunology)
  • Cytoprotection (drug effects)
  • Humans
  • Jurkat Cells
  • Leukemia, T-Cell (metabolism)
  • Liver Regeneration
  • Poly (ADP-Ribose) Polymerase-1
  • Poly(ADP-ribose) Polymerases (metabolism)
  • Proteins (pharmacology, physiology)
  • Proto-Oncogene Proteins c-bcl-2 (metabolism)
  • Signal Transduction (drug effects)
  • Vincristine (pharmacology)

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