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A single histrelin implant is effective for 2 years for treatment of central precocious puberty.

Abstract
We investigated whether a "yearly" histrelin implant would provide pubertal suppression when left in place for 2 years. Equivalent suppression was observed when comparing 12 and 24 months in 33 children with central precocious puberty. A single implant for 2 years reduces cost and number of implant procedures.
AuthorsKatherine A Lewis, Andrea K Goldyn, Karen W West, Erica A Eugster
JournalThe Journal of pediatrics (J Pediatr) Vol. 163 Issue 4 Pg. 1214-6 (Oct 2013) ISSN: 1097-6833 [Electronic] United States
PMID23809043 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Mosby, Inc. All rights reserved.
Chemical References
  • Drug Implants
  • Gonadotropin-Releasing Hormone
  • Luteinizing Hormone
  • histrelin
Topics
  • Child
  • Child, Preschool
  • Drug Implants
  • Female
  • Gonadotropin-Releasing Hormone (administration & dosage, analogs & derivatives, therapeutic use)
  • Humans
  • Hypothalamo-Hypophyseal System (drug effects)
  • Luteinizing Hormone (blood)
  • Male
  • Puberty, Precocious (drug therapy)
  • Sex Factors
  • Time Factors

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