HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Letrozole stimulation in endometrial preparation for cryopreserved-thawed embryo transfer in women with polycystic ovarian syndrome: a pilot study.

AbstractOBJECTIVE:
To study the efficiency of letrozole, an aromatase inhibitor, in endometrial preparation for cryopreserved-thawed embryo transfer (FET) in women with polycystic ovarian syndrome (PCOS).
DESIGN:
Retrospective observational study.
PATIENTS:
One hundred and twenty patients with PCOS who met the inclusion criteria for the study.
MEASUREMENTS:
We assessed in vitro fertilization outcomes in one hundred and twenty patients with PCOS (148 cycles) who were prepared for and underwent FET between June 2011 and December 2012. Patients were prepared for FET using artificial hormone cycles induced with oestrogen and progesterone supplementation (n = 76), letrozole stimulation (n = 40) or hMG stimulation (n = 32).
RESULTS:
There were no differences in demographic characteristics between the groups, except that the letrozole group had a higher incidence of embryo transfer failure in the past. The letrozole stimulation group had a significantly higher maximal endometrial thickness and significantly higher rates of clinical pregnancy per transfer, ongoing pregnancy per transfer and implantation, compared with the artificial and hMG stimulation groups. Differences in these parameters between the artificial and hMG stimulation groups were not significant.
CONCLUSION:
Using letrozole stimulation in endometrial preparation for cryopreserved-thawed embryo transfer in patients with PCOS may be associated with better outcomes than using hormonal manipulation or hMG stimulation.
AuthorsYan-Jun Hu, Yue-Zhou Chen, Yi-Min Zhu, He-Feng Huang
JournalClinical endocrinology (Clin Endocrinol (Oxf)) Vol. 80 Issue 2 Pg. 283-9 (Feb 2014) ISSN: 1365-2265 [Electronic] England
PMID23808904 (Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
Copyright© 2013 John Wiley & Sons Ltd.
Chemical References
  • Aromatase Inhibitors
  • Nitriles
  • Triazoles
  • letrozole
Topics
  • Adult
  • Aromatase Inhibitors (therapeutic use)
  • Cryopreservation
  • Embryo Transfer (methods)
  • Endometrium (drug effects, physiopathology)
  • Female
  • Fertilization in Vitro
  • Humans
  • Male
  • Nitriles (therapeutic use)
  • Pilot Projects
  • Polycystic Ovary Syndrome (physiopathology)
  • Pregnancy
  • Pregnancy Rate
  • Retrospective Studies
  • Triazoles (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: