Abstract | CASE REPORT: RESULTS: Changes to the apheresis collection variables and instrumentation did not improve the yields in the next three collections. The laboratory investigation demonstrated that there was an interfering substance in the patient's plasma that was causing falsely high peripheral blood CD34+ cell values and that the low CD34+ cell yields in the collections were consistent with the actual peripheral blood CD34+ cell value. Based on this finding and after discussion with the clinical service, the patient then received plerixafor to increase the number of circulating CD34+ cells before Collections 6 and 7. The patient went on to achieve the target CD34+ cell dose and subsequently underwent a successful autologous transplant with full hematopoietic engraftment. CONCLUSION: This case demonstrates the importance of timely and critical review of laboratory results in the context of the specific patient. This case exemplifies how diligent review of laboratory results and open communication among the various teams can positively affect patient outcomes.
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Authors | Courtney J Liwski, Douglas J Padley, Michael P Gustafson, Jeffrey L Winters, Dennis A Gastineau, Eapen K Jacob |
Journal | Transfusion
(Transfusion)
Vol. 54
Issue 3
Pg. 541-4
(Mar 2014)
ISSN: 1537-2995 [Electronic] United States |
PMID | 23808629
(Publication Type: Case Reports, Journal Article)
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Copyright | © 2013 American Association of Blood Banks. |
Chemical References |
- Antigens, CD34
- Granulocyte Colony-Stimulating Factor
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Topics |
- Antigens, CD34
(metabolism)
- Blood Component Removal
- Granulocyte Colony-Stimulating Factor
(metabolism)
- Hematopoietic Stem Cell Mobilization
- Hematopoietic Stem Cell Transplantation
- Hematopoietic Stem Cells
(cytology, metabolism)
- Humans
- Male
- Middle Aged
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