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[Molecular genetic basis of age-related macular degeneration].

Abstract
Visual loss due to age-related macular degeneration (AMD) is caused by one or both forms of advanced disease: "wet" (neovascular) or "dry" (geographic atrophy). Immune system plays a central role in pathogenesis and progression of both AMD forms. Main genetic polymorphisms associated with risk of AMD development and progression were found to be genes that regulate inflammation especially in complement factor H gen (1q31 locus) and 10q26 locus (PLEKHAI/ARMS2/HTRA1). Association of response to treatment and genotype was shown in patients with AMD. Complete characterization of both common and rare alleles that influence AMD risk is necessary for accurate determination of individual genetic risk as well as identification of new targets for therapeutic intervention.
AuthorsÉ V Boĭko, S V Churashov, T A Kamilova
JournalVestnik oftalmologii (Vestn Oftalmol) 2013 Mar-Apr Vol. 129 Issue 2 Pg. 86-90 ISSN: 0042-465X [Print] Russia (Federation)
PMID23808188 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • Complement Factor H
Topics
  • Complement Factor H (genetics)
  • Complement Pathway, Alternative (genetics)
  • Disease Progression
  • Genetic Predisposition to Disease
  • Geographic Atrophy (complications, immunology)
  • Glaucoma, Neovascular (complications, immunology)
  • Humans
  • Macular Degeneration (etiology, genetics, physiopathology, therapy)
  • Mutation
  • Pharmacogenetics (methods)
  • Polymorphism, Genetic
  • Precision Medicine

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