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Non-ionic surfactant vesicles simultaneously enhance antitumor activity and reduce the toxicity of cantharidin.

AbstractOBJECTIVE:
The objective of the present study was to prepare cantharidin-entrapped non-ionic surfactant vesicles (CTD-NSVs) and evaluate their potential in enhancing the antitumor activities and reducing CTD's toxicity.
METHODS AND RESULTS:
CTD-NSVs were prepared by injection method. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and flow cytometry analysis showed that CTD-NSVs could significantly enhance in vitro toxicity against human breast cancer cell line MCF-7 and induce more significant cell-cycle arrest in G0/G1 phase. Moreover, Hoechst 33342 staining implicated that CTD-NSVs induced higher apoptotic rates in MCF-7 cells than free CTD solution. In vivo therapeutic efficacy was investigated in imprinting control region mice bearing mouse sarcoma S180. Mice treated with 1.0 mg/kg CTD-NSVs showed the most powerful antitumor activity, with an inhibition rate of 52.76%, which was significantly higher than that of cyclophosphamide (35 mg/kg, 40.23%) and the same concentration of free CTD (1.0 mg/kg, 31.05%). In addition, the acute toxicity and liver toxicity of CTD were also distinctly decreased via encapsulating into NSVs.
CONCLUSION:
Our results revealed that NSVs could be a promising delivery system for enhancing the antitumor activity and simultaneously reducing the toxicity of CTD.
AuthorsWei Han, Shengpeng Wang, Rixin Liang, Lan Wang, Meiwan Chen, Hui Li, Yitao Wang
JournalInternational journal of nanomedicine (Int J Nanomedicine) Vol. 8 Pg. 2187-96 ( 2013) ISSN: 1178-2013 [Electronic] New Zealand
PMID23807847 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Drug Carriers
  • Surface-Active Agents
  • Cantharidin
Topics
  • Analysis of Variance
  • Animals
  • Antineoplastic Agents (chemistry, pharmacology, toxicity)
  • Apoptosis (drug effects)
  • Cantharidin (chemistry, pharmacology, toxicity)
  • Cell Cycle (drug effects)
  • Cell Survival (drug effects)
  • Drug Carriers (chemistry, toxicity)
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • MCF-7 Cells
  • Male
  • Mice
  • Mice, Inbred ICR
  • Surface-Active Agents (chemistry, toxicity)
  • Xenograft Model Antitumor Assays

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