Abstract | OBJECTIVE: While patients with gastrointestinal cancer are at increased risk of cholangitis, it is less clear whether cholangitis is also a marker for occult gastrointestinal cancer. If an undiagnosed cancer obstructs the bile duct system and causes cholangitis, the short-term risk of cancer will appear increased. However, an increased long-term risk of cancer may originate from chronic inflammatory processes. We assessed the risk of a gastrointestinal cancer diagnosis subsequent to a cholangitis diagnosis during a 17-year period in Denmark. DESIGN: We conducted a nationwide population-based cohort study by linking Danish medical registries during 1994-2010. We quantified the excess risk of cancer in cholangitis patients using relative (standardised incidence ratio; SIR) and absolute (excess absolute risk per 1000 person-years at risk; EAR) risk calculations. RESULTS: 4333 patients with cholangitis (including 178 with primary sclerosing cholangitis) were followed for 17 222 person-years. During the follow-up period, 477 gastrointestinal cancers occurred versus 59 expected, corresponding to a SIR of 8.12 (95% CI 7.41 to 8.88). Risk was increased mainly for cancer in the small intestine (SIR 18.2; 95% CI 8.69 to 33.4), liver (SIR 16.3; 95% CI 11.6 to 22.2), gallbladder and biliary tract (SIR 70.9; 95% CI 59.0 to 84.4) and pancreas (SIR 31.7; 95% CI 27.8 to 36.0). During the first 6 months of follow-up, 314 patients were diagnosed with gastrointestinal cancer, corresponding to a SIR of 49.8 (95% CI 44.4 to 55.6) and an EAR of 175. CONCLUSIONS: Cholangitis is a marker of occult gastrointestinal cancer.
|
Authors | Kirstine Kobberøe Søgaard, Rune Erichsen, Jennifer Leigh Lund, Dóra Körmendiné Farkas, Henrik Toft Sørensen |
Journal | Gut
(Gut)
Vol. 63
Issue 2
Pg. 356-61
(Feb 2014)
ISSN: 1468-3288 [Electronic] England |
PMID | 23804559
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Topics |
- Aged
- Cholangitis
(complications)
- Cohort Studies
- Denmark
(epidemiology)
- Female
- Follow-Up Studies
- Gastrointestinal Neoplasms
(epidemiology, etiology)
- Humans
- Incidence
- Male
- Middle Aged
- Registries
- Risk Assessment
- Risk Factors
|