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[Effects of whole lung lavage on pulmonary function and exercise capacity in patients with pneumoconiosis].

AbstractOBJECTIVE:
To investigate the effects of whole lung lavage (WLL) on the pulmonary function and exercise capacity in patients with pneumoconiosis.
METHODS:
Forty-one patients with pneumoconiosis who quit dust-exposed work not more than 6 months before underwent WLL. Clinical symptom assessment, pulmonary function test, and cardiopulmonary exercise test were performed before and one week after WLL, and the results were compared.
RESULTS:
The patients with pneumoconiosis showed no significant changes in clinical symptoms after WLL. At one week after WLL, the patients with pneumoconiosis showed nonsignificant increases in forced vital capacity, forced expiratory volume in one second (FEV1.0), and percent predicted FEV1 (P > 0.05); peak oxygen uptake (peak VO₂) increased from 2140.6 ± 353.2 ml/min before WLL to 2374.6 ± 362.4 ml/min after WLL, percent predicted peak VO₂ increased from 82.2 ± 13.7% before WLL to 91.0 ± 14.0% after WLL, peak VO₂/kg increased from 30.6 ± 3.5 ml/min×kg before WLL to 34.2 ± 3.7 ml/min×kg after WLL, and ventilatory equivalent for carbon dioxide decreased from 30.6 ± 3.1 before WLL to 26.1 ± 2.7 after WLL (P < 0.05).
CONCLUSION:
WLL can remarkably improve the oxygen uptake and ventilatory efficiency in patients with pneumoconiosis during exercise, so it can improve the exercise capacity of these patients.
AuthorsShao-wei Zhou, Ling Mao, Jin-ming Liu, Wen-lan Yang, Jin Shi, Yue Zhang, Lu-qin Bian
JournalZhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi) Vol. 31 Issue 6 Pg. 428-31 (Jun 2013) ISSN: 1001-9391 [Print] China
PMID23803542 (Publication Type: English Abstract, Journal Article)
Topics
  • Adult
  • Bronchoalveolar Lavage
  • Exercise Tolerance
  • Humans
  • Lung (physiopathology)
  • Middle Aged
  • Pneumoconiosis (physiopathology, therapy)

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