Abstract | BACKGROUND: MATERIALS AND METHODS: We conducted a case-control study of 218 northern Indian lung cancer patients along with 238 healthy controls, to assess any association between CYP1A1, GSTM1 and GSTT1 polymorphisms, either separately or in combination, with the likelihood of development of Lung cancer in our population. RESULTS: We observed a significant difference in the GSTT1 null deletion frequency in this population when compared with other populations (OR=1.87, 95%CI: 1.25-2.80-0.73, P=0.002). However, GSTM1 null genotype was found associated with lung cancer in the non-smoking subgroup. (P=0.170). CONCLUSIONS: Our study showed the GSTT1 null polymorphism to be associated with smoking-induced lung cancer and the GSTM1 null polymorphism to have a link with non-smoking related lung cancer.
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Authors | R K Shukla, A R Tilak, C Kumar, S Kant, A Kumar, B Mittal, S Bhattacharya |
Journal | Asian Pacific journal of cancer prevention : APJCP
(Asian Pac J Cancer Prev)
Vol. 14
Issue 5
Pg. 3345-9
( 2013)
ISSN: 2476-762X [Electronic] Thailand |
PMID | 23803127
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- CYP1A1 protein, human
- Cytochrome P-450 CYP1A1
- glutathione S-transferase T1
- Glutathione Transferase
- glutathione S-transferase M1
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Topics |
- Case-Control Studies
- Cytochrome P-450 CYP1A1
(genetics)
- Female
- Gene Frequency
- Genetic Association Studies
- Genetic Predisposition to Disease
- Glutathione Transferase
(genetics)
- Humans
- India
- Lung Neoplasms
(genetics)
- Male
- Middle Aged
- Polymorphism, Genetic
- Smoking
- Surveys and Questionnaires
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