Possible roles of the xenobiotic transporter P-glycoproteins encoded by the MDR1 3435 C>T gene polymorphism in differentiated thyroid cancers.

Abstract

BACKGROUND:

P-glycoprotein (Pgp), encoded by the multidrug resistance 1 (MDR1) gene, is an efflux transporter which plays an important role in pharmacokinetics. The current preliminary study was designed to determine associations between a germ-line polymorphism in the MDR1 gene with differentiated thyroid carcinoma (DTC).

MATERIALS AND METHODS:

In the current case-control study, 60 differentiated thyroid cancers (DTC)- 45 papillary TC (PTC), 9 follicular TC(FTC) and 6 well-differentiated tumors of uncertain malignant potential (WDT-UMP) were examined. Results were compared to a healthy control group (n=58) from the same population. Genomic DNA was extracted from peripheral blood with EDTA and the target gene was genotyped by real-time PCR.

RESULTS:

Carriers of the variant allele of MDR1 exon 26 polymorphism were at 2.8-fold higher risk of DTC than the control group (odds ratio [OR]: 0.3805, 95% confidence interval [Cl]: 0.1597-0.9065 (p> 0.046).

CONCLUSIONS:

Presented results suggest that the MDR1 3435TT genotype might influence risk of development of DTC and that the CC genotype might be linked to a poor prognosis. Large-scale studies are now needed to validate this association.

• Authors: Semra Ozdemir, Ahmet Uludag, Fatma Silan, Sinem Yalcintepe Atik, Bulent Turgut, Ozturk Ozdemir
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 14 Issue 5 Pg. 3213-7 ( 2013) ISSN: 2476-762X [Electronic] Thailand
• PMID: 23803106 (Publication Type: Comparative Study, Journal Article)

Chemical References

• ABCB1 protein, human
• ATP Binding Cassette Transporter, Subfamily B
• ATP Binding Cassette Transporter, Subfamily B, Member 1
• Biomarkers, Tumor

Topics

• ATP Binding Cassette Transporter, Subfamily B
• ATP Binding Cassette Transporter, Subfamily B, Member 1 (genetics)
• Adenocarcinoma, Follicular (genetics, pathology)
• Adult
• Aged
• Biomarkers, Tumor (genetics)
• Carcinoma, Papillary (genetics, pathology)
• Case-Control Studies
• Female
• Follow-Up Studies
• Genetic Predisposition to Disease
• Genotype
• Humans
• Male
• Middle Aged
• Neoplasm Staging
• Polymorphism, Genetic (genetics)
• Prognosis
• Real-Time Polymerase Chain Reaction
• Thyroid Neoplasms (genetics, pathology)