CP-84,657, a potent polyether anticoccidial related to portmicin and produced by Actinomadura sp.

Abstract

A new polyether antibiotic CP-84,657 (C45H78O14) was isolated by solvent extraction from the fermentation broth of Actinomadura sp. (ATCC 53708). Following purification by column chromatography and crystallization, the structure of CP-84,657 was elucidated by spectroscopic (NMR and MS) methods. The absolute stereochemistry was determined by a single crystal X-ray analysis of the corresponding rubidium salt. CP-84,657 is among the most potent anticoccidal agents known, effectively controlling the Eimeria species that are the major causative agents of chicken coccidiosis at doses of 5 mg/kg or less in feed. It is also active in vitro against certain Gram-positive bacteria, as well as the spirochete, Treponema hyodysenteriae.

• Authors: J P Dirlam, A M Belton, J Bordner, W P Cullen, L H Huang, Y Kojima, H Maeda, H Nishida, S Nishiyama, J R Oscarson
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 43 Issue 6 Pg. 668-79 (Jun 1990) ISSN: 0021-8820 [Print] England
• PMID: 2380113 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Coccidiostats
• Furans
• Pyrans
• CP 84657
• salinomycin

Topics

• Actinomycetales (classification, metabolism)
• Animals
• Anti-Bacterial Agents (analysis, biosynthesis, isolation & purification, pharmacology)
• Bacteria (drug effects)
• Chickens
• Coccidiosis (drug therapy)
• Coccidiostats (analysis, isolation & purification, pharmacology)
• Crystallography
• Eimeria (drug effects)
• Fermentation
• Furans (analysis, isolation & purification, pharmacology)
• Magnetic Resonance Spectroscopy
• Mass Spectrometry
• Molecular Structure
• Pyrans (pharmacology)