Abstract |
The efficacy of 5-iodo-2-deoxyuridine ( IUDR) as a radiosensitizer when administered by continuous infusion into the cerebral spinal fluid (CSF) of the lateral cerebral ventricle was evaluated in a 9L gliosarcoma rat brain tumor model. Stereotactic implantation of a 5 x 10(4) tumor cell suspension into the left caudate nucleus was carried out in four groups of 10 rats each. Control animals had a median survival of 16.9 days (range 16-21 days). IUDR, 8.4 mg over 7 days administered by continuous infusion into the left lateral ventricle produced a slight survival advantage (median survival 21.5 days, range 12-56). Irradiation of the entire brain, 8 Gy on days 4, 6 and 7 after tumor cell implantation also produced a slight improvement in survival (median 19.5 days, range 17-34). The combination of radiation and IUDR infusion into the CSF produced a marked survival advantage (median 30.5, range 22-54) compared to the control and single modality treatment groups. This is the first demonstration of the effectiveness of IUDR as a radiosensitizer when administered into the lateral cerebral ventricle in the treatment of an intraparenchymal brain tumor.
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Authors | M Deutsch, A B Rewers, S Redgate, E R Fisher, S S Boggs |
Journal | International journal of radiation oncology, biology, physics
(Int J Radiat Oncol Biol Phys)
Vol. 19
Issue 1
Pg. 85-7
(Jul 1990)
ISSN: 0360-3016 [Print] United States |
PMID | 2380099
(Publication Type: Journal Article)
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Chemical References |
- Radiation-Sensitizing Agents
- Idoxuridine
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Topics |
- Animals
- Brain Neoplasms
(drug therapy, radiotherapy)
- Death
- Glioma
(drug therapy, radiotherapy)
- Idoxuridine
(administration & dosage, therapeutic use)
- Injections, Intraventricular
- Male
- Neoplasm Transplantation
- Radiation-Sensitizing Agents
(administration & dosage, therapeutic use)
- Rats
- Rats, Inbred F344
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