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Polypeptide N-acetylgalactosaminyl transferase 3 independently predicts high-grade tumours and poor prognosis in patients with renal cell carcinomas.

AbstractBACKGROUND:
The polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts) family of enzymes regulates the initial steps of mucin-type O-glycosylation. N-acetylgalactosaminyltransferases might show novel patterns of GalNAc-T glycosylation on tumour-derived proteins, which could influence cancer biology, but its mechanisms are unclear. We investigated the association of GalNAc-T3 and -T6 expressions with clinicopathological features and prognoses of patients with renal cell carcinomas (RCCs).
METHODS:
Expressions of GalNAc-T3/6 and cell-adhesion molecules were analysed immunohistochemically in 254 paraffin-embedded tumour samples of patients with RCC.
RESULTS:
Of 138 GalNAc-T3+ cases, 46 revealed significant co-expression with GalNAc-T6. N-acetylgalactosaminyltransferases-3+ expression showed a close relationship to poor clinical performance and large tumour size, or pathologically high Fuhrman's grading, and presence of vascular invasion and necrosis. The GalNAc-T3-positivity potentially suppressed adhesive effects with a significantly low β-catenin expression. Univariate and multivariate analyses showed the GalNAc-T3+ group, but not the GalNAc-T6+ group, to have significantly worse survival rates.
CONCLUSION:
N-acetylgalactosaminyltransferases-3 expression independently predicts high-grade tumour and poor prognosis in patients with RCC, and may offer a therapeutic target against RCC.
AuthorsS Kitada, S Yamada, A Kuma, S Ouchi, T Tasaki, A Nabeshima, H Noguchi, K-Y Wang, S Shimajiri, R Nakano, H Izumi, K Kohno, T Matsumoto, Y Sasaguri
JournalBritish journal of cancer (Br J Cancer) Vol. 109 Issue 2 Pg. 472-81 (Jul 23 2013) ISSN: 1532-1827 [Electronic] England
PMID23799843 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers, Tumor
  • N-Acetylgalactosaminyltransferases
  • polypeptide N-acetylgalactosaminyltransferase
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor (genetics, metabolism)
  • Carcinoma, Renal Cell (enzymology, pathology)
  • Cell Line, Tumor
  • Cohort Studies
  • Female
  • Humans
  • Kidney Neoplasms (enzymology, pathology)
  • Male
  • Middle Aged
  • N-Acetylgalactosaminyltransferases (genetics, metabolism)
  • Neoplasm Grading
  • Prognosis
  • Retrospective Studies

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