Mitomycin-C: 'a ray of hope' in refractory corrosive esophageal strictures.

Abstract

Increasingly frequent dilation may become a self-defeating cycle in refractory stricture as recurrent trauma enhance, scar formation, and ultimately recurrence and potential worsening of the stricture. In 12 patients of caustic induced esophageal stricture, who failed to respond despite rigorous dilatation regimen for more than one year, a trial of topical mitomycin-C application to improve dilatation results was undertaken, considering the recently reported efficacy and safety of this agent. Mitomycin-C was applied for 2-3 minutes at the strictured esophageal segment after dilation with wire-guided Savary-Gilliard dilator. Patient was kept nil by mouth for 2-3 hours. After 4-6 sessions of mitomycin-C treatment, resolution of symptoms and significant improvement in dysphagia score and periodic dilatation index was seen in all 12 patients. Mitomycin-C topical application may be a useful strategy in refractory corrosive esophageal strictures and salvage patients from surgery.

• Authors: N Nagaich, S Nijhawan, P Katiyar, R Sharma, M Rathore
• Journal: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus (Dis Esophagus) Vol. 27 Issue 3 Pg. 203-5 (Apr 2014) ISSN: 1442-2050 [Electronic] United States
• PMID: 23796367 (Publication Type: Journal Article, Observational Study)
• Copyright: © 2013 Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus.

Chemical References

• Antibiotics, Antineoplastic
• Mitomycin

Topics

• Administration, Topical
• Antibiotics, Antineoplastic (administration & dosage, therapeutic use)
• Burns, Chemical (complications)
• Deglutition Disorders (etiology)
• Dilatation (instrumentation)
• Esophageal Stenosis (drug therapy, etiology)
• Humans
• Mitomycin (administration & dosage, therapeutic use)
• Recurrence
• Severity of Illness Index
• Treatment Failure