Emerging applications of metabolomics in studying chemopreventive phytochemicals.

Abstract

Phytochemicals from diet and herbal medicines are under intensive investigation for their potential use as chemopreventive agents to block and suppress carcinogenesis. Chemical diversity of phytochemicals, together with complex metabolic interactions between phytochemicals and biological system, can overwhelm the capacity of traditional analytical platforms, and thus pose major challenges in studying chemopreventive phytochemicals. Recent progresses in metabolomics have transformed it to become a robust systems biology tool, suitable for examining both chemical and biochemical events that contribute to the cancer prevention activities of plant preparations or their bioactive components. This review aims to discuss the technical platform of metabolomics and its existing and potential applications in chemoprevention research, including identifying bioactive phytochemicals in plant extracts, monitoring phytochemical exposure in humans, elucidating biotransformation pathways of phytochemicals, and characterizing the effects of phytochemicals on endogenous metabolism and cancer metabolism.

• Authors: Lei Wang, Chi Chen
• Journal: The AAPS journal (AAPS J) Vol. 15 Issue 4 Pg. 941-50 (Oct 2013) ISSN: 1550-7416 [Electronic] United States
• PMID: 23794098 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review)

Chemical References

• Anticarcinogenic Agents
• Phytochemicals
• Plant Extracts

Topics

• Animals
• Anticarcinogenic Agents (isolation & purification, therapeutic use)
• Chemoprevention (methods, trends)
• Humans
• Metabolomics (methods, trends)
• Neoplasms (drug therapy, prevention & control)
• Phytochemicals (isolation & purification, therapeutic use)
• Plant Extracts (isolation & purification, therapeutic use)