Oral bullous eruption after taking lisinopril--case report and literature review.

Abstract

Drug-induced lesions of oral mucosa are well-established side effect of different commonly used drugs. A female patient under treatment for hypertension with an angiotensin-converting enzyme inhibitor (ACE inhibitor), lisinopril, developed blisters and ulcerations on oral mucosa 3 weeks after lisinopril intake. Due to clinical finding drug-induced pemphigus was considered. However, direct and indirect immunofluorescence anal-ysis revealed no autoantibodies that are commonly present in pemphigus while histological study suggested allergic reaction. Lisinopril was discontinued from further therapy and after a month after her first arrival patient has experienced complete remission of the disease. This case raises the question, whether the term pemphigus in drug-induced reactions could be used when immunopathological criteria for pemphigus are not fulfilled.

• Authors: Marinka Baričević, Marinka Mravak Stipetić, Mirna Situm, Branka Marinović, Sven Seiwerth, Denis Baričević, Božana Lončar
• Journal: Wiener klinische Wochenschrift (Wien Klin Wochenschr) Vol. 125 Issue 13-14 Pg. 408-11 (Jul 2013) ISSN: 1613-7671 [Electronic] Austria
• PMID: 23794071 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Angiotensin-Converting Enzyme Inhibitors
• Antihypertensive Agents
• Lisinopril

Topics

• Angiotensin-Converting Enzyme Inhibitors (adverse effects)
• Antihypertensive Agents (adverse effects)
• Blister (chemically induced, diagnosis)
• Diagnosis, Differential
• Drug Eruptions (diagnosis, etiology)
• Humans
• Lisinopril (adverse effects)
• Mouth Diseases (chemically induced, diagnosis)