Association of HLA-DRB1*15 and HLADQB1*06 with SLE in Saudis.

Abstract

BACKGROUND AND OBJECTIVES:

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by humoral autoimmunity. The etiology of SLE is thought to be multifactorial including environmental, hormonal, and genetic factors. The human leukocyte antigen (HLA) has extensively been associated with the susceptibility to SLE; however, the association is heterogeneous among different ethnic groups. The aim of this study was to determine the association of HLA-A, HLA-B, HLA-DRB1, and HLA-DQB1 with SLE susceptibility in the Saudi population.

DESIGN AND SETTINGS:

A total of 86 consecutive SLE patients attending the rheumatology clinic at King Abdulaziz Medical City, Riyadh, were recruited for this study.

METHODS:

HLA types were determined by the polymerase chain reaction sequence-specific oligonucleotide (PCR-SSP) method in 86 patients and 356 control subjects.

RESULTS:

The following HLA alleles were found to be positively associated with SLE: HLA-A*29 (OR=2.70; 95% CI=1.03-7.08; P=.0035), HLA-B*51 (OR=1.81; 95% CI=1.17-2.79; P=.0066), HLA-DRB1*15 (OR=1.45; 95% CI=0.98-2.29; P=.063), and HLA-DQB1*06 (OR=1.67; 95% CI=1.19-2.36; P=.0032), whereas HLA-DRB1*16 was negatively associated with the disease (OR=0.18; 95% CI=0.02-1.3; P=.055). HLA-DRB1*15 haplotypes were significantly associated with SLE (OR=2.01, 95% CI=1.20-3.68, P=.008); this was mainly due to the HLADRB1*15-DQB1*06 association.

CONCLUSIONS:

Our data suggest an association between MHC class I and class II (HLA-A*29, HLA-B*51, HLA-DRB1*15, and HLA-DQB1*06) and susceptibility to SLE in the Saudi population. HLA-DRB1*15-DQB1*06 haplotype showed the highest risk factor for the disease that is similar to what was seen in the African American patients, suggesting shared susceptibility genetic factors among these ethnic groups.

• Authors: Saleh Al-Motwee, Dunia Jawdat, Ghassan S Jehani, Hanan Anazi, Abdullah Shubaili, Paul Sutton, Aytul F Uyar, Ali H Hajeer
• Journal: Annals of Saudi medicine (Ann Saudi Med) 2013 May-Jun Vol. 33 Issue 3 Pg. 229-34 ISSN: 0975-4466 [Electronic] Saudi Arabia
• PMID: 23793423 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-DQ beta-Chains
• HLA-DQB1 antigen
• HLA-DRB1 Chains
• HLA-DRB1*15 antigen

Topics

• Adolescent
• Adult
• Alleles
• Case-Control Studies
• Child
• Female
• Genes, MHC Class I (genetics)
• Genes, MHC Class II (genetics)
• Genetic Predisposition to Disease
• HLA-DQ beta-Chains (genetics)
• HLA-DRB1 Chains (genetics)
• Haplotypes
• Humans
• Lupus Erythematosus, Systemic (genetics)
• Male
• Middle Aged
• Polymerase Chain Reaction
• Risk Factors
• Saudi Arabia
• Young Adult