Mitosis and histopathology in rat liver during methylclofenapate-induced hyperplasia.

Abstract

Liver hyperplasia was induced in rats by daily administration of methylclofenapate (25 mg/kg by gavage). An increase in the incidence of colchicine-arrested metaphases was observed with peaks occurring at 40 h (1.3%), 64 h (6.4%) and 84 h (6.8%) after the start of treatment. This response contrasted with the much larger (21.3%) peak in arrested metaphases at 36 h after partial hepatectomy, but was still unexpectedly large in comparison with the S-phase response to methylclofenapate reported in a previous study. Progressive hypertrophic histopathological changes were apparent during the whole course of treatment.

• Authors: A Bybee, J A Styles, S L Beck, D Blackburn
• Journal: Cancer letters (Cancer Lett) Vol. 52 Issue 2 Pg. 95-100 (Jul 16 1990) ISSN: 0304-3835 [Print] Ireland
• PMID: 2379140 (Publication Type: Journal Article)

Chemical References

• Butyrates
• Clofenapate
• Colchicine

Topics

• Animals
• Butyrates
• Chemical and Drug Induced Liver Injury
• Clofenapate
• Colchicine (pharmacology)
• Hyperplasia (chemically induced)
• Liver Diseases (pathology)
• Liver Regeneration
• Male
• Mitosis (drug effects)
• Mitotic Index
• Rats
• Rats, Inbred Strains