Cytotoxic impact of phenolics from Lamiaceae species on human breast cancer cells.

Abstract

The aim of this study was to evaluate the cytotoxicity of dried aqueous extracts from Thymus serpyllum (ExTs), Thymus vulgaris (ExTv), Majorana hortensis (ExMh), and Mentha piperita (ExMp), and the phenolic compounds caffeic acid (CA), rosmarinic acid (RA), lithospermic acid (LA), luteolin-7-O-glucuronide (Lgr), luteolin-7-O-rutinoside (Lr), eriodictiol-7-O-rutinoside (Er), and arbutin (Ab), on two human breast cancer cell lines: Adriamycin-resistant MCF-7/Adr and wild-type MCF-7/wt. In the MTT assay, ExMh showed the highest cytotoxicity, especially against MCF-7/Adr, whereas ExMp was the least toxic; particularly against MCF-7/wt cells. RA and LA exhibited the strongest cytotoxicity against both MCF-7 cell lines, over 2-fold greater than CA and Lgr, around 3-fold greater than Er, and around 4- to 7-fold in comparison with Lr and Ab. Except for Lr and Ab, all other phytochemicals were more toxic against MCF-7/wt, and all extracts exhibited higher toxicity against MCF-7/Adr. It might be concluded that the tested phenolics exhibited more beneficial properties when they were applied in the form of extracts comprising their mixtures.

• Authors: Izabela Berdowska, Bogdan Zieliński, Izabela Fecka, Julita Kulbacka, Jolanta Saczko, Andrzej Gamian
• Journal: Food chemistry (Food Chem) Vol. 141 Issue 2 Pg. 1313-21 (Nov 15 2013) ISSN: 1873-7072 [Electronic] England
• PMID: 23790919 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents, Phytogenic
• Phenols
• Plant Extracts

Topics

• Antineoplastic Agents, Phytogenic (toxicity)
• Breast Neoplasms (physiopathology)
• Cell Proliferation (drug effects)
• Female
• Humans
• Lamiaceae (chemistry)
• MCF-7 Cells
• Phenols (toxicity)
• Plant Extracts (toxicity)