Antimicrobial efficacy of a novel silver hydrogel dressing compared to two common silver burn wound dressings: Acticoat™ and PolyMem Silver(®).

Abstract

A novel burn wound hydrogel dressing has been previously developed which is composed of 2-acrylamido-2-methylpropane sulfonic acid sodium salt with silver nanoparticles. This study compared the antimicrobial efficacy of this novel dressing to two commercially available silver dressings; Acticoat™ and PolyMem Silver(®). Three different antimicrobial tests were used: disc diffusion, broth culture, and the Live/Dead(®) Baclight™ bacterial viability assay. Burn wound pathogens (P. aeruginosa, MSSA, A. baumannii and C. albicans) and antibiotic resistant strains (MRSA and VRE) were tested. All three antimicrobial tests indicated that Acticoat™ was the most effective antimicrobial agent, with inhibition zone lengths of 13.9-18.4mm. It reduced the microbial inocula below the limit of detection (10(2)CFU/ml) and reduced viability by 99% within 4h. PolyMem Silver(®) had no zone of inhibition for most tested micro-organisms, and it also showed poor antimicrobial activity in the broth culture and Live/Dead(®) Baclight™ assays. Alarmingly, it appeared to promote the growth of VRE. The silver hydrogel reduced most of the tested microbial inocula below the detection limit and decreased bacterial viability by 94-99% after 24h exposure. These results support the possibility of using this novel silver hydrogel as a burn wound dressing in the future.

• Authors: Benjawan Boonkaew, Margit Kempf, Roy Kimble, Pitt Supaphol, Leila Cuttle
• Journal: Burns : journal of the International Society for Burn Injuries (Burns) Vol. 40 Issue 1 Pg. 89-96 (Feb 2014) ISSN: 1879-1409 [Electronic] Netherlands
• PMID: 23790588 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Ltd and ISBI. All rights reserved.

Chemical References

• Acrylamides
• Acticoat
• Alkanesulfonates
• Anti-Infective Agents, Local
• Polyesters
• Polyethylenes
• Polymem
• Polyurethanes
• Silver
• 2-acrylamido-2-methylpropanesulfonate
• Glycerol

Topics

• Acinetobacter baumannii (drug effects)
• Acrylamides (pharmacology)
• Alkanesulfonates (pharmacology)
• Anti-Infective Agents, Local (pharmacology)
• Bandages, Hydrocolloid
• Burns (therapy)
• Candida albicans (drug effects)
• Enterococcus (drug effects)
• Glycerol (pharmacology)
• Humans
• Metal Nanoparticles
• Methicillin-Resistant Staphylococcus aureus (drug effects)
• Microbial Sensitivity Tests
• Polyesters (pharmacology)
• Polyethylenes (pharmacology)
• Polyurethanes (pharmacology)
• Pseudomonas aeruginosa (drug effects)
• Silver (pharmacology)
• Staphylococcus aureus (drug effects)