[Optimal conditions for preservation of isolated heart using creatine phosphate and vitamin E (an experimental study)].

Abstract

Functional and structural safety of the myocardium following 6-hour preservation at 4-6 degrees C in ion-balanced cardioplegic solution alone or in combination with pharmacological corrective was evaluated in rats. Langendorff and Neely model of isolated heart perfusion was used. The addition of creatine phosphate in a conservation of 10 mM/l to the solution or donor pretreatment with 70 mg/kg vitamin E was found to potentiate the protective properties of the solution under deep hypothermia. The combined use of the agents proved to warrant the initial intact structural and functional status of the rat myocardium.

• Authors: M L Semenovskiĭ, N A Onishchenko, V T Chkheidze, A I Krylova
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 109 Issue 5 Pg. 465-8 (May 1990) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Optimizatsiia usloviĭ konservatsii izolirovannogo serdtsa s pomoshch'iu kreatinfosfata i vitamina E (éksperimental'noe issledovanie).
• PMID: 2378958 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Cardioplegic Solutions
• Phosphocreatine
• Vitamin E

Topics

• Animals
• Cardioplegic Solutions
• Heart Arrest, Induced
• Heart Transplantation
• Male
• Organ Preservation
• Phosphocreatine (pharmacology)
• Rats
• Time Factors
• Vitamin E (pharmacology)