Microbubbles from gas-generating perfluorohexane nanoemulsions for targeted temperature-sensitive ultrasonography and synergistic HIFU ablation of tumors.

Abstract

A special "small to big" temperature-responsive phase-transformation strategy based on the "acoustic droplet vaporization (ADV)" mechanism is developed for efficient targeted ultrasonography and synergistic high intensity focused ultrasound (HIFU) cancer surgery by engineering targeted nanoemulsions, which is systematically evaluated and successfully demonstrated in vitro, ex vivo, and in vivo.

• Authors: Yang Zhou, Zhigang Wang, Yu Chen, Hongxia Shen, Zhenchun Luo, Ao Li, Qi Wang, Haitao Ran, Pan Li, Weixiang Song, Zhu Yang, Hangrong Chen, Zhibiao Wang, Guangmin Lu, Yuanyi Zheng
• Journal: Advanced materials (Deerfield Beach, Fla.) (Adv Mater) Vol. 25 Issue 30 Pg. 4123-30 (Aug 14 2013) ISSN: 1521-4095 [Electronic] Germany
• PMID: 23788403 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Emulsions
• Fluorocarbons
• Gases
• perflexane

Topics

• Animals
• Cell Line, Tumor
• Emulsions (chemistry, therapeutic use)
• Fluorocarbons (chemical synthesis, therapeutic use)
• Gases (chemical synthesis, therapeutic use)
• High-Intensity Focused Ultrasound Ablation (methods)
• Materials Testing
• Mice
• Mice, Nude
• Microbubbles (therapeutic use)
• Nanoparticles (chemistry, therapeutic use, ultrastructure)
• Neoplasms, Experimental (pathology, therapy)
• Temperature
• Treatment Outcome