Efficacy and safety of the treatment: combination of benazepril/lercanidipine vs. benazepril alone in patients with mild-to-moderate hypertension.

Abstract

BACKGROUND:

Combination therapy is an effective method to reduce the blood pressure (BP) for patients with hypertension. This study was performed to evaluate the efficacy and safety of benazepril/lercanidipine compared with benazepril alone in patients with mild-to-moderate hypertension.

METHODS:

One hundred and eighty-one patients with mild-to-moderate primary hypertension were assigned in this randomized, single-blind, parallel-group study and were randomly divided into group A (benazepril 10 mg/lercanidipine 10 mg) and group B (benazepril 10 mg) for 8 weeks. At 4 weeks, the dosage of Benazepril was titrated up to 20 mg if the diastolic blood pressure (DBP) remained ≥ 90 mmHg. BP control and side effects were evaluated at the end of 1, 4 and 8 weeks.

RESULTS:

The baseline characteristics of the two groups were similar. The BP in both groups decreased from the baseline (P < 0.05). At the end of 4 and 8 weeks, Benazepril/Lercanidipine produced greater BP reduction than Benazepril alone (P < 0.05). The comparison of the rate of BP control for the benazepril/lercanidipine and benazepril groups at the end of 1, 4, and 8 weeks were 41.2% vs. 37.6% (P > 0.05), 67.1% vs. 44.7% (P < 0.05), and 71.8% vs. 45.9% (P < 0.05). There was no significant difference of side effects between the two groups.

CONCLUSION:

The benazepril/lercanidipine combination is more effective in reducing BP than benazepril alone, while it does not increase the incidence of side effects.

• Authors: Ting Chen, Guang-Hui Chen, Ting-Shu Yang, Zhen-Yu Zhong, Wei-Shuai An, Xiao-Xia Zhang, Jia-Dan Li
• Journal: Chinese medical journal (Chin Med J (Engl)) Vol. 126 Issue 12 Pg. 2286-90 (Jun 2013) ISSN: 2542-5641 [Electronic] China
• PMID: 23786940 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Angiotensin-Converting Enzyme Inhibitors
• Benzazepines
• Calcium Channel Blockers
• Dihydropyridines
• benazepril
• lercanidipine

Topics

• Aged
• Angiotensin-Converting Enzyme Inhibitors (therapeutic use)
• Benzazepines (administration & dosage, adverse effects, therapeutic use)
• Blood Pressure (drug effects)
• Calcium Channel Blockers (administration & dosage)
• Dihydropyridines (administration & dosage, adverse effects)
• Drug Therapy, Combination
• Female
• Humans
• Hypertension (drug therapy)
• Male
• Middle Aged
• Single-Blind Method