Abstract | STUDY OBJECTIVE: DESIGN: We evaluated the safety and efficacy of aeABLC adjunct therapy for fungal lung disease in a retrospective study of 32 immunosuppressed adults. All values are given as ± standard deviation. SETTING: National Cancer Institute-designated Comprehensive Cancer Center. PATIENTS: MEASUREMENT AND MAIN RESULTS: High-dose corticosteroids were administered during aeABLC in 28% of patients. Fungal lung disease was proven or probable in 41% of patients. Most patients (78%) received concurrent systemic antifungal therapy for a median of 14 ± 18 days before aeABLC. The median cumulative aeABLC dose was 1050 ± 2368 mg, and the median duration of aeABLC therapy was 28 ± 130 days. Most patients (78%) received 50 mg aeABLC twice daily. Partial or complete resolution of fungal lung disease was noted in 50% of patients. In three patients (9%) modest cough, mild bronchospasm, and transient chest pain with accompanying nausea and vomiting resolved completely after discontinuation of aeABLC. No patient required hospitalization for drug toxicity or had a serious (grade III or IV) drug-related adverse event. CONCLUSION:
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Authors | Amar Safdar, Gilhen H Rodriguez |
Journal | Pharmacotherapy
(Pharmacotherapy)
Vol. 33
Issue 10
Pg. 1035-43
(Oct 2013)
ISSN: 1875-9114 [Electronic] United States |
PMID | 23784915
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 Pharmacotherapy Publications, Inc. |
Chemical References |
- Antifungal Agents
- Glucocorticoids
- liposomal amphotericin B
- Amphotericin B
|
Topics |
- Adult
- Aged
- Amphotericin B
(administration & dosage, adverse effects, therapeutic use)
- Antifungal Agents
(administration & dosage, adverse effects, therapeutic use)
- Female
- Glucocorticoids
(administration & dosage, therapeutic use)
- Hematopoietic Stem Cell Transplantation
- Humans
- Immunocompromised Host
- Lung Diseases, Fungal
(etiology, prevention & control)
- Male
- Middle Aged
- Neoplasms
(pathology)
- Neutropenia
(epidemiology)
- Retrospective Studies
- Severity of Illness Index
- Young Adult
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