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Does urinary trypsin inhibitor have a role in acute lung injury induced by pulmonary contusion: a basic research in a model of rats.

Abstract
We evaluate the efficacy of urinary trypsin inhibitor (UTI) on inflammation, oxidative stress, hypoxemia, and diseased lesion in a rat model of acute lung injury induced by blunt trauma. Rats were allocated to 4 groups. One group served as normal control. The other 3 groups had a moderate pulmonary contusion. Except for 1 sham group administrated saline, 1 group was administrated low-dose UTI (20,000 U/kg), and another group was administrated high-dose UTI (50,000 U/kg). Twelve hours after contusion, neutrophil counting in bronchoalveolar lavage fluid (BALF) was performed and tumor necrosis factor α level and albumin level in BALF was tested. Lung tissue malondialdehyde levels, superoxide dismutase, and catalase activity was investigated, and blood gas analysis and contusion volume quantification using 3-dimensional computed tomography were performed. High-dose UTI significantly decreased neutrophil count and tumor necrosis factor α level in BALF (P<0.05) and decreased albumin level in BALF but without significance. Lung tissue malondialdehyde levels was significantly reduced, whereas superoxide dismutase and catalase activity were elevated by UTI with significance (P<0.05) especially high-dose UTI. No statistical significance was seen in the change in arterial oxygen partial pressure (PaO2) and contusion volume by UTI (P>0.05). UTI has a dose-dependent trend to ameliorate inflammatory and oxygen stress in pulmonary contusion-induced acute lung injury. However, the effect on hypoxemia and contusion lesion and the best administration regime should be investigated in future study.
AuthorsShaohua Wang, Jin Wang, Xi Chen, Zheng Ruan, Jin Zheng, Jie Zhang
JournalAmerican journal of therapeutics (Am J Ther) 2014 Nov-Dec Vol. 21 Issue 6 Pg. 447-52 ISSN: 1536-3686 [Electronic] United States
PMID23782766 (Publication Type: Journal Article)
Chemical References
  • Glycoproteins
  • Tumor Necrosis Factor-alpha
  • Malondialdehyde
  • Superoxide Dismutase
  • urinastatin
  • Oxygen
Topics
  • Acute Lung Injury (drug therapy, etiology)
  • Animals
  • Bronchoalveolar Lavage Fluid
  • Contusions (complications, drug therapy)
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Glycoproteins (administration & dosage, pharmacology)
  • Hypoxia (drug therapy)
  • Inflammation (drug therapy, etiology)
  • Male
  • Malondialdehyde (metabolism)
  • Oxidative Stress (drug effects)
  • Oxygen (metabolism)
  • Partial Pressure
  • Rats
  • Rats, Sprague-Dawley
  • Superoxide Dismutase (metabolism)
  • Tumor Necrosis Factor-alpha

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