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Prognostic value of organic anion transporting polypeptide 1B3 and copper transporter 1 expression in endometrial cancer patients treated with paclitaxel and carboplatin.

Abstract
Paclitaxel and carboplatin (TC) chemotherapy is an effective and well-tolerated regimen against advanced endometrial cancer. Organic anion transporting polypeptide 1B3 (OATP1B3) and copper transporter 1 (CTR1) are critical for the uptake of paclitaxel and carboplatin, respectively. This study aimed to address the prognostic impact of OATP1B3 and CTR1 in endometrial cancer patients treated with adjuvant TC chemotherapy. We immunohistochemically evaluated the expressions of OATP1B3 and CTR1 in 47 stage III endometrial cancers. The high expression levels of OATP1B3 were significantly correlated with type I tumor (P = 0.0005). In univariate analysis, high expression levels of OATP1B3 (P = 0.047) and CTR1 (P = 0.009) were significantly associated with longer disease-free survival (DFS) and longer overall survival (OS), respectively. The patients with tumors showing high expression levels of at least one of OATP1B3 and CTR1 had potentially longer DFS (P = 0.058) and significantly longer OS (P = 0.003) sin the univariate analysis. Combined OATP1B3/CTR1 expression was the sole independent prognostic factor for longer OS in the multivariate analysis (P = 0.013). Our findings suggest that combined OATP1B3/CTR1 expression is a possible predictive/prognostic factor for a good outcome in stage III endometrial cancer patients treated with adjuvant TC chemotherapy.
AuthorsNaoki Ogane, Masanori Yasuda, Yoichi Kameda, Tomoyuki Yokose, Hisamori Kato, Ayumi Itoh, Satoshi Nishino, Yumi Hashimoto, Shingo Kamoshida
JournalBiomedical research (Tokyo, Japan) (Biomed Res) Vol. 34 Issue 3 Pg. 143-51 (Jun 2013) ISSN: 1880-313X [Electronic] Japan
PMID23782748 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Biomarkers, Tumor
  • Cation Transport Proteins
  • Copper Transporter 1
  • Organic Anion Transporters, Sodium-Independent
  • SLC31A1 protein, human
  • SLCO1B3 protein, human
  • Solute Carrier Organic Anion Transporter Family Member 1B3
  • Carboplatin
  • Paclitaxel
Topics
  • Adult
  • Aged
  • Antineoplastic Agents (therapeutic use)
  • Biomarkers, Tumor (genetics, metabolism)
  • Carboplatin (therapeutic use)
  • Carcinoma (diagnosis, drug therapy, genetics, mortality)
  • Cation Transport Proteins (genetics, metabolism)
  • Chemotherapy, Adjuvant
  • Copper Transporter 1
  • Endometrial Neoplasms (diagnosis, drug therapy, genetics, mortality)
  • Female
  • Gene Expression
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Neoplasm Staging
  • Organic Anion Transporters, Sodium-Independent (genetics, metabolism)
  • Paclitaxel (therapeutic use)
  • Prognosis
  • Solute Carrier Organic Anion Transporter Family Member 1B3
  • Survival Analysis
  • Treatment Outcome

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