Abstract | BACKGROUND AND OBJECTIVES: MATERIALS AND METHODS: All neonates from mothers with ITP born between 1980 and 2011 were included. Platelet counts during the first 10 days, presence of ICH and postnatal treatment were recorded. Maternal characteristics were analysed as possible risk factors for severe neonatal thrombocytopenia. RESULTS: CONCLUSION: In this cohort, severe neonatal thrombocytopenia occurs more frequently than previously reported. To maintain a platelet count above 50 × 10(9) /l, often multiple transfusions and IVIG are required. Multiple transfusions may be avoided by starting IVIG, when platelet count falls below 50 × 10(9) /l after the first platelet transfusion.
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Authors | N M van der Lugt, A van Kampen, F J Walther, A Brand, E Lopriore |
Journal | Vox sanguinis
(Vox Sang)
Vol. 105
Issue 3
Pg. 236-43
(Oct 2013)
ISSN: 1423-0410 [Electronic] England |
PMID | 23782272
(Publication Type: Journal Article)
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Copyright | © 2013 International Society of Blood Transfusion. |
Chemical References |
- Immunoglobulins, Intravenous
- Prednisone
|
Topics |
- Adult
- Blood Platelets
(immunology)
- Female
- Humans
- Immunoglobulins, Intravenous
(therapeutic use)
- Infant, Newborn
- Platelet Count
- Platelet Transfusion
- Prednisone
(therapeutic use)
- Pregnancy
- Pregnancy Complications, Hematologic
(immunology)
- Purpura, Thrombocytopenic, Idiopathic
(immunology)
- Recurrence
- Risk Factors
- Thrombocytopenia, Neonatal Alloimmune
(immunology, therapy)
- Treatment Outcome
- Young Adult
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