Sustainable complete remission in recurrence yolk sac tumor patient treated with tandem high-dose chemotherapy and autologous stem cell.

Abstract

A 21-year-old lady diagnosed with Stage 3 ovarian yolk sac tumor (YST) underwent primary cytoreductive fertility sparing surgery, followed by conventional courses of platinum-based chemotherapy and etoposide. Recurrence at cul-da-sac was noted after a short period of remission and secondary debulking performed followed by four cycles of conventional chemotherapy. The patient's disease progressed despite courses of treatments. A joint team management including a hematologist was commenced following the failure of conventional chemotherapies. Two cycles of high-dose chemotherapy (HDCT) with ifosfamide/cisplatin/etoposide (ICE) regimen, followed by autologous stem cell transplantation (ASCT) were given. With this salvage treatment, she remained in complete remission and disease-free for more than 30 months, while maintaining her reproductive function. These approaches appear to be effective as a salvage treatment in selected cases of patients with ovarian germ cell tumor, especially those who failed primary conventional chemotherapy.

• Authors: N A Abdullah, P N Wang, K G Huang, A S Adlan, J Casanova
• Journal: European journal of gynaecological oncology (Eur J Gynaecol Oncol) Vol. 34 Issue 2 Pg. 183-5 ( 2013) ISSN: 0392-2936 [Print] Singapore
• PMID: 23781595 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Endodermal Sinus Tumor (therapy)
• Female
• Humans
• Neoplasm Recurrence, Local (therapy)
• Ovarian Neoplasms (therapy)
• Stem Cell Transplantation
• Transplantation, Autologous