Prediction of octreotide efficacy by electrogastrography in the treatment of patients with esophageal variceal hemorrhage.

Abstract

Our aim is to investigate the significance of electrogastrography in the treatment of esophageal variceal hemorrhage with octreotide. Electrogastrography was performed in patients with esophageal variceal hemorrhage before and during the treatment consisting of various doses of octreotide (25 ug h(-1) group and 50 ug h(-1) group). The dominant power of electrogastrography and its relationship with the hemostatic efficacy of octreotide treatment were evaluated. Dominant power of electrogastrography decreased significantly during treatment with octreotide (P < 0.05). The reduction in the amplitude of dominant power in the 50 ug h(-1) group was significantly larger than in the 25 ug h(-1) group (P < 0.05), and it was correlated with hemostatic efficacy of octreotide treatment. We conclude that octreotide treatment in patients with esophageal variceal hemorrhage can result in a significant decrease of dominant power, which correlates with the hemostatic efficacy of octreotide, so the change of dominant power could be used as a predictor of evaluating the treatment efficacy of octreotide in esophageal variceal hemorrhage patients.

• Authors: Yixiong Zhang, Zhiliing Liu, Xiaoliang Liu, Xiaotong Han, Yucheng Zhou, Yan Cao, Xingwen Zhang
• Journal: Physiological measurement (Physiol Meas) Vol. 34 Issue 7 Pg. 799-812 (Jul 2013) ISSN: 1361-6579 [Electronic] England
• PMID: 23780564 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Octreotide

Topics

• Adult
• Electrodes
• Esophageal and Gastric Varices (complications, drug therapy)
• Female
• Hemorrhage (complications, drug therapy)
• Hemostasis (drug effects)
• Humans
• Male
• Middle Aged
• Myography (methods)
• Octreotide (pharmacology, therapeutic use)
• Treatment Outcome