Abstract | SCOPE: Previous studies found that phloretin (PT) and phlorizin (PZ) could inhibit glucose transport, with PT being a better inhibitor of lipid peroxidation. This study aimed to evaluate the antiobesity effects of PT and PZ in 3T3-L1 cells and if they can modulate the relationship between adipocytes and macrophages. METHODS AND RESULTS: CONCLUSION: This study suggests that PT is more effective than PZ at increasing lipolysis in adipocytes. In addition, PT also suppresses inflammatory response in macrophage that is stimulated by differentiated media from 3T3-L1 cells.
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Authors | Wen-Chung Huang, Wei-Tien Chang, Shu-Ju Wu, Pei-Yin Xu, Nai-Chun Ting, Chian-Jiun Liou |
Journal | Molecular nutrition & food research
(Mol Nutr Food Res)
Vol. 57
Issue 10
Pg. 1803-13
(Oct 2013)
ISSN: 1613-4133 [Electronic] Germany |
PMID | 23776070
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
- Anti-Obesity Agents
- NF-kappa B
- Transcription Factors
- Tumor Necrosis Factor-alpha
- Phlorhizin
- Mitogen-Activated Protein Kinases
- AMP-Activated Protein Kinases
- Sterol Esterase
- Phloretin
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Topics |
- 3T3-L1 Cells
- AMP-Activated Protein Kinases
(metabolism)
- Adipocytes
(cytology, drug effects, metabolism)
- Adipogenesis
(drug effects)
- Animals
- Anti-Obesity Agents
(pharmacology)
- Cell Differentiation
- Cell Line, Tumor
- Cell Survival
(drug effects)
- Coculture Techniques
- Inflammation
(drug therapy)
- Lipolysis
(drug effects)
- Macrophages
(cytology, drug effects, metabolism)
- Mice
- Mitogen-Activated Protein Kinases
(metabolism)
- NF-kappa B
(metabolism)
- Phloretin
(pharmacology)
- Phlorhizin
(pharmacology)
- Phosphorylation
- Signal Transduction
- Sterol Esterase
(metabolism)
- Transcription Factors
(metabolism)
- Tumor Necrosis Factor-alpha
(metabolism)
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