Abstract | OBJECTIVES: METHODS: We examined CEL- MODY patients and control subjects by rapid, endoscopic secretin test and dynamic magnetic resonance imaging of the pancreas. The findings were related to the subjects' clinical status. RESULTS: The CEL- MODY patients displayed severely reduced acinar function and moderately reduced ductal function of the pancreas compared with control subjects. Surprisingly, CEL- MODY patients did not have clinical or biochemical signs of malnutrition, except for subnormal levels of vitamin E. Vitamin E levels seemed to be directly related to pancreatic acinar function. CONCLUSIONS: Pancreatic exocrine dysfunction in CEL- MODY is associated with severely reduced acinar and moderately reduced ductal dysfunction. Despite severely reduced exocrine pancreatic function, CEL- MODY patients revealed only minor signs of malnutrition.
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Authors | Erling Tjora, Gaute Wathle, Trond Engjom, Friedemann Erchinger, Anders Molven, Lage Aksnes, Ingfrid Salvesen Haldorsen, Georg Dimcevski, Pål Rasmus Njølstad, Helge Ræder |
Journal | Pancreas
(Pancreas)
Vol. 42
Issue 7
Pg. 1078-84
(Oct 2013)
ISSN: 1536-4828 [Electronic] United States |
PMID | 23770712
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Secretin
- CEL protein, human
- Lipase
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Topics |
- Adolescent
- Adult
- Aged
- Case-Control Studies
- Child
- Diabetes Mellitus, Type 2
(enzymology, genetics, physiopathology)
- Female
- Humans
- Lipase
(genetics)
- Magnetic Resonance Imaging
- Male
- Malnutrition
(etiology)
- Middle Aged
- Mutation
- Nutritional Status
- Pancreas, Exocrine
(physiopathology)
- Pancreatic Diseases
(enzymology, genetics, physiopathology)
- Pancreatic Function Tests
- Secretin
- Vitamin E Deficiency
(etiology)
- Young Adult
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