Abstract |
The activation of Group II metabotropic glutamate 2/3 (mGlu2/3) receptors reduces the excessive glutamate release that is hypothesized to be associated with neurodegenerative and psychiatric disorders. LY379268 is a highly potent mGlu2/3 receptor agonist that has shown efficacy in several animal models of stroke, epilepsy, drug abuse, schizophrenia, and pain. The present study investigated the effects of LY379268 on anxiety-like behavior in rats assessed in the light/dark and open field tests. The effects of LY379268 on motility in a locomotor activity chamber were also investigated in rats. Administration of the two lower doses of LY379268 used (0.3 and 1mg/kg) did not influence rats' performance either in the light/dark or in the open field test. Importantly, the administration of a higher LY379268 dose (3mg/kg) induced decrease in the number of transitions between the light and dark chambers and time spent in the light chamber compared to the vehicle-treated animals in the light/dark test. In the open field test, rats that received 3mg/kg LY379268 made fewer entries and spent less time in the central zone of the apparatus, exhibited a decrease of rearing episodes, but displayed higher grooming activity compared to controls. Nevertheless, the 3mg/kg dose did not alter locomotor activity compared with vehicle-treated rats in a motility test. The present results indicate that the highest LY379268 dose used in this study induced an anxiety-like effect in the light/dark and open field tests that cannot be attributed to changes in locomotor activity, while lower doses had no effect.
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Authors | Vasilios Grivas, Athina Markou, Nikolaos Pitsikas |
Journal | European journal of pharmacology
(Eur J Pharmacol)
Vol. 715
Issue 1-3
Pg. 105-10
(Sep 05 2013)
ISSN: 1879-0712 [Electronic] Netherlands |
PMID | 23769742
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 Elsevier B.V. All rights reserved. |
Chemical References |
- Amino Acids
- Bridged Bicyclo Compounds, Heterocyclic
- LY 379268
- Receptors, Metabotropic Glutamate
- metabotropic glutamate receptor 2
- metabotropic glutamate receptor 3
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Topics |
- Amino Acids
(adverse effects, pharmacology)
- Animals
- Anxiety
(chemically induced)
- Bridged Bicyclo Compounds, Heterocyclic
(adverse effects, pharmacology)
- Darkness
- Dose-Response Relationship, Drug
- Locomotion
(drug effects)
- Male
- Rats
- Rats, Wistar
- Receptors, Metabotropic Glutamate
(agonists)
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