Abstract | BACKGROUND: The role of osmotic and oxidative stress has been strongly implicated in the pathogenesis of cataract. Nigerloxin, a fungal metabolite, has been shown to possess aldose reductase inhibition and improved antioxidant defense system in lens of diabetic rats. In the present study, the beneficial influence of nigerloxin was investigated in galactose-induced cataract in experimental animals. METHODS: RESULTS: CONCLUSIONS:
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Authors | Bharathinagar S Suresha, Krishnapura Srinivasan |
Journal | Current eye research
(Curr Eye Res)
Vol. 38
Issue 10
Pg. 1064-71
(Oct 2013)
ISSN: 1460-2202 [Electronic] England |
PMID | 23767695
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Benzoates
- Polymers
- Sulfhydryl Compounds
- nigerloxin
- polyol
- Tryptophan
- Aldehyde Reductase
- Glutathione
- Propane
- Galactose
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Topics |
- Aldehyde Reductase
(antagonists & inhibitors)
- Animals
- Antioxidants
(pharmacology)
- Aspergillus niger
(chemistry)
- Benzoates
(pharmacology)
- Cataract
(chemically induced, drug therapy, metabolism)
- Diabetes Mellitus, Experimental
(metabolism)
- Galactose
(pharmacology)
- Glutathione
(metabolism)
- Lens, Crystalline
(drug effects, metabolism)
- Lipid Peroxidation
(drug effects)
- Male
- Oxidative Stress
(drug effects)
- Polymers
(metabolism)
- Propane
(analogs & derivatives, pharmacology)
- Rats
- Rats, Wistar
- Sulfhydryl Compounds
(metabolism)
- Tryptophan
(metabolism)
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