The ferroquine antimalarial conundrum: redox activation and reinvasion inhibition.

Abstract

Metal health: Ferroquine is a ferrocene-based analogue of the antimalarial drug chloroquine. In addition to the primary mechanism of quinoline action, fluorescent probe studies in infected red blood cells show another mechanism is at work. It is based on the production of HO(·) in the acidic and oxidizing environment of the digestive vacuole of the malaria parasite and implies that, with ferroquine, reinvasion can be inhibited.

• Authors: Faustine Dubar, Christian Slomianny, Jamal Khalife, Daniel Dive, Hadidjatou Kalamou, Yann Guérardel, Philippe Grellier, Christophe Biot
• Journal: Angewandte Chemie (International ed. in English) (Angew Chem Int Ed Engl) Vol. 52 Issue 30 Pg. 7690-3 (Jul 22 2013) ISSN: 1521-3773 [Electronic] Germany
• PMID: 23765846 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Aminoquinolines
• Antimalarials
• Ferrous Compounds
• Metallocenes
• Hydroxyl Radical
• ferroquine

Topics

• Aminoquinolines (therapeutic use)
• Antimalarials (therapeutic use)
• Erythrocytes (drug effects, parasitology)
• Ferrous Compounds (therapeutic use)
• Humans
• Hydroxyl Radical (chemistry)
• Malaria, Falciparum (drug therapy, parasitology)
• Metallocenes
• Oxidation-Reduction
• Plasmodium falciparum (pathogenicity)