Abstract | PURPOSE: METHODS: A case-control study was performed to analyze 53 SNPs in 11 miRNA biogenesis pathway genes in 356 patients (200 patients with NF1 and 156 patients with both NF1 and MPNST) in China. Association analysis was performed in an additive genetic model by logistics regression. RESULTS: Four SNPs (DDX5 rs1991401, OR=1.79, 95% CI, 1.34-2.38, P=7.90 × 10(-5); DROSHA rs10719, OR=1.64, 95% CI, 1.23-2.20, P=8.76 × 10(-4); AGO2 rs7005286, OR=0.48, 95% CI, 0.32-0.72, P=3.46 × 10(-4); GEMIN4 rs7813, OR=0.50, 95% CI, 0.34-0.72, P=2.65 × 10(-4)) were significantly associated with MPNST risk. A strong gene-dose effect with increased MPNST risk (P for trend<0.001) was observed. CONCLUSIONS: Genetic variants in the miRNA biogenesis pathway genes may modify MPNST risk both individually and jointly.
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Authors | Yuxiong Weng, Yanhua Chen, Jianghai Chen, Yutian Liu, Tengfei Bao |
Journal | Cancer epidemiology
(Cancer Epidemiol)
Vol. 37
Issue 6
Pg. 913-6
(Dec 2013)
ISSN: 1877-783X [Electronic] Netherlands |
PMID | 23763827
(Publication Type: Comparative Study, Journal Article, Retracted Publication)
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Copyright | Copyright © 2013 Elsevier Ltd. All rights reserved. |
Chemical References |
- Biomarkers, Tumor
- MicroRNAs
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Topics |
- Adult
- Asian People
(genetics)
- Biomarkers, Tumor
(genetics)
- Case-Control Studies
- China
(epidemiology)
- Female
- Follow-Up Studies
- Genotype
- Humans
- Male
- MicroRNAs
(genetics)
- Neurilemmoma
(epidemiology, genetics)
- Neurofibromatosis 1
(epidemiology, genetics)
- Polymorphism, Single Nucleotide
(genetics)
- Prognosis
- Risk Factors
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