[Experimental evaluation of reamberin and cytoflavin effects on the course and outcome of acute burn injury].

Abstract

Survival rate, average life expectancy of victims, parameters of the acid - base balance, gas composition of blood, and morphological structure of internal organs have been studied in acute experiments on a group of 120 rats with burn injury of IIIB degree (20% of body surface) against early introduction of antihypoxants reamberin and cytoflavin. It is established that the introduction of antihypoxants reliably prevents the development of typical pathologic processes and hypoxemia, reduces expressiveness of organ dysfunction and extent of mophological changes in internal organs, and increases 1.5 - 2.5 times the survival rate of heavily damaged animals in the acute period of burn injury.

• Authors: E V Zinov'ev, Iu V Nesterov, T O Lagvilava
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 76 Issue 4 Pg. 39-44 ( 2013) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 23762989 (Publication Type: Journal Article)

Chemical References

• Drug Combinations
• Reamberin
• Succinates
• cytoflavin
• Niacinamide
• Meglumine
• Flavin Mononucleotide
• Inosine Diphosphate

Topics

• Acute Disease
• Animals
• Burns (drug therapy, pathology, physiopathology)
• Drug Combinations
• Drug Evaluation, Preclinical
• Female
• Flavin Mononucleotide (pharmacology)
• Hypoxia (pathology, physiopathology, prevention & control)
• Inosine Diphosphate (pharmacology)
• Male
• Meglumine (analogs & derivatives, pharmacology)
• Niacinamide (pharmacology)
• Rats
• Succinates (pharmacology)